Synthesis of IL-2 mRNA in cells of rat hypothalamic structures after injection of short peptides.

Bulletin of experimental biology and medicine2005PMID: 16224591

Animal StudyEpitalon

Plain Language Summary

Synthetic peptides Vilon, Epitalon, and Cortagen were shown to modulate the expression of the interleukin-2 gene in rat brain hypothalamic structures. The effects varied depending on the timing and route of administration, demonstrating these peptides can influence immune-related gene activity directly in the brain.

Abstract

In situ hybridization on paraffin sections of the rat brain showed that synthetic peptides Vilon, Epithalon, and Cortagen modulated the expression of IL-2 gene in vivo in cells of some hypothalamic structures depending on the terms and routes of administration.

Authors

Kazakova, T B; Barabanova, S V; Novikova, N S; Glushikhina, M S; Khavinson, V Kh; Malinin, V V; Korneva, E A