Glyprolines and semax prevent stress-induced microcirculatory disturbances in the mesentery.

Bulletin of experimental biology and medicine20034 citationsPMID: 14968154

Plain Language Summary

This study showed that Semax and glyprolines prevent stress-induced microcirculatory disturbances in the mesentery. The neuropeptide protected against vascular dysfunction triggered by stress, demonstrating protective effects on the microvascular system.

Abstract

One-hour immobilization stress considerably disturbed microcirculation in the mesentery: blood flow in small mesenteric vessels decreased or stopped and numerous hemorrhages appeared. Lymphatic vessels lost spontaneous activity and did not respond to norepinephrine. Administration of Semax and glyprolines 1 h before stress decreased the severity of stress-induced microcirculatory disturbances. PGP and GP were most effective in this respect.

Authors

Kopylova, G N; Smirnova, E A; Sanzhieva, L Ts; Umarova, B A; Lelekova, T V; Samonina, G E