[A method for reproducing amnesia in mice by the complex extremal exposure].

Eksperimental'naia i klinicheskaia farmakologiia2003PMID: 12924240

Animal StudySemax

Plain Language Summary

This study developed a method for reproducing amnesia in mice using complex extreme stress exposure, and evaluated Semax's ability to prevent memory impairment. The nootropic peptide showed protective effects against stress-induced amnesia.

Abstract

It is suggested to reproduce a retrograde amnesia in mice by means of a complex extremal action: emaciating swim in cold water with simultaneous wheel rotation. It was found that nootropes such as pyracetam, mexidol, semax, nooglutil, acephen, and noopept fully or completely prevent from the amnesia development.

Authors

Iasnetsov, V V; Provornova, N A