[Neuroprotective effects of semax in MPTP-induced disturbances of brain dopamine system].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova20021 citationPMID: 12587264

Animal StudySemax

Plain Language Summary

This animal study demonstrated neuroprotective effects of Semax in MPTP-induced disturbances of the brain dopamine system, a model of Parkinson's disease. Semax treatment preserved dopaminergic neuron function, suggesting therapeutic potential for neurodegenerative conditions involving dopamine system damage.

Abstract

Effects of an ACTH (4-10) analogue Semax (MEHFPGP) on behaviour of white rats with MPTP-induced disturbances of brain DA-system have been studied. It was shown that MPTP administration (25 mg/kg) reduced motor activity and auhmented the anxiety level in rats. Semax administration (daily intranasal 0.2 mg/kg) attenuated behaviour disturbances induced by neurotoxin. The observed protective action of Semax in rats with MFTP-induced DA system disturbances may be due to both its modulating influence on the brain DA system and peptide neuroprotective effects.

Authors

Levitskaia, N G; Sebentsova, E A; Andreeva, L A; Alfeeva, L Iu; Kamenskiĭ, A A; Miasoedov, N F