[Tissue-specific action of peptides in tissue culture of rats of various ages].

Advances in gerontology = Uspekhi gerontologii2002PMID: 12096446

Animal StudyEpitalon

Plain Language Summary

Epitalon and its parent compound Epithalamin were tested alongside other peptide preparations in tissue cultures from rats of various ages. Both peptides exerted tissue-specific effects on explants from the cerebral cortex, brain subcortical structures, liver, and thymus, demonstrating organ-selective bioregulatory activity.

Abstract

There was studied the effect of polypeptide preparations isolated from the cerebral cortex (Cortexin), epiphysis (Epithalamin), liver (Hepalin), thymus (Thymalin) and small synthetic peptides--Cortagen, Epitalon, Livagen, Vilon on the development of explants from the cerebral cortex, brain subcortical structures, liver and thymus of rats of various age. With respect to the applied concentrations of the investigated peptides, they exerted tissue-specific effects in the organ-typical culture of animal tissues.

Authors

Khavinson, V Kh; Malinin, V V; Chalisova, N I; Grigor'ev, E I