Epitalon (Ala-Glu-Asp-Gly) produced a threefold increase in nocturnal melatonin peaks in old rhesus monkeys and extended lifespan in mice and fruit flies. It also postponed vision loss in Campbell rats with hereditary retinal degeneration, with its broad effects likely mediated through tissue-specific transcription factors in the pineal gland and retina.
Khavinson, V Kh; Golubev, A G