[Effect of vilon and epithalone on induction and growth of induced bladder neoplasms in rats].

Voprosy onkologii2001PMID: 11785104

Animal StudyEpitalon

Plain Language Summary

Vilon significantly reduced bladder tumor incidence in rats exposed to a chemical carcinogen, lowering it from 75.5% in controls to 56%, and inhibited early neoplastic changes. However, epitalon did not show a similar inhibitory effect on bladder carcinogenesis in this model.

Abstract

Experimental data on the effect of peptides--Vilon (Lys-Glu) and Epitalon (Ala-Glu-Asp-Gly)--on induction of urinary bladder tumors in rats are presented. Treatment with Vilon was followed by a significant fall in tumor incidence in 56% of experimental animals, as compared with 75.5% in control, as well as inhibition of early-onset neoplastic changes in the bladder mucosa. No inhibitory effect of Epitalon was recorded.

Authors

Pliss, G B; Mel'nikov, A S; Malinin, V V; Khavinson, V Kh