Tissue-specific effects of peptides.

Bulletin of experimental biology and medicine2001PMID: 11713572

Animal StudyEpitalon

Plain Language Summary

Epitalon stimulated growth of brain subcortical tissue explants in organotypic cultures, demonstrating tissue-specific activity corresponding to its origin from pineal gland peptide complexes. This tissue specificity was consistent across multiple synthetic peptides, each selectively stimulating growth in tissues matching their source cytomedins.

Abstract

Synthetic peptides (cytogens) Cortagen, Epithalon, Livagen, and Vilon stimulated the growth of explants from rat brain cortex, subcortical structures, liver, and thymus, respectively, in organotypic cultures. These peptides produced tissue-specific effects: they stimulated the growth of explants from tissues, whose cytomedins (peptide complexes) were used for chemical synthesis.

Authors

Khavinson, V K