[Effect of epithalone on growth kinetics and functional morphology of M-1 sarcoma].

Voprosy onkologii2001PMID: 11710291

Animal StudyEpitalon

Plain Language Summary

Epitalon inhibited the growth of transplanted sarcoma M-1 in rats at a dose of 2.5 micrograms/kg, with the tumor-suppressing effect lasting two weeks after the injection course ended. The mechanism involved disruption of tumor blood flow, leading to hemorrhagic necrosis and increased apoptosis of tumor cells rather than direct cytostatic action.

Abstract

The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg). The effect lasted for two weeks after injection course. Decrease in proliferative activity was not associated with the drug's immediate cytostatic action on tumor cells. The specific mechanism of the drug's action via blood flow was shown by morphological signs of hemorrhagic necrosis of tumor and increased apoptosis of tumor cells.

Authors

Khavinson, V Kh; Iuzhakov, V V; Kvetnoĭ, I M; Malinin, V V