Effects of peptides on generation of reactive oxygen species in subcellular fractions of Drosophila melanogaster.

Bulletin of experimental biology and medicine2001PMID: 11687853

Plain Language Summary

The effects of epitalon (Ala-Glu-Asp-Gly) and vilon on free radical processes were studied in Drosophila melanogaster. Vilon inhibited reactive oxygen species generation in mitochondria but stimulated it in the cytosol, with sex- and age-related differences observed in both reactive oxygen species generation and antioxidant activity.

Abstract

We studied the effects of Epithalon (Ala-Glu-Asp-Gly) and Vilon (Lys-Glu) on free radical processes in highly inbred HA(+)line of Drosophila melanogaster. Vilon inhibited generation of reactive oxygen species in mitochondria, but stimulated this process in the cytosol. We found sex- and age-related differences in the generation of reactive oxygen species and cytosol antioxidant activity.

Authors

Khavinson, V K; Myl'nikov, S V; Oparina, T I; Arutyunyan, A V