Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.

Neuro endocrinology letters2001PMID: 11524632

Plain Language Summary

Epitalon significantly stimulated evening melatonin synthesis in senescent rhesus monkeys, thereby normalizing the circadian rhythm of cortisol secretion. This demonstrates epitalon's ability to restore disrupted neuroendocrine regulation in aging primates.

Abstract

UNLABELLED: The OBJECTIVE of this research was to investigate the regulatory effect of Epitalon on the production of melatonin and cortisol in senescent monkeys. MATERIAL AND METHODS: We investigated the character of melatonin and cortisol secretion by immunoferment assay in Epitalon-administered female Macaca mulatta in different age periods. RESULTS: Epitalon was proven to significantly stimulate melatonin synthesis in senescent monkeys in the evening, thereby normalising the circadian rhythm of cortisol secretion.

Authors

Khavinson, V; Goncharova, N; Lapin, B