[Effect of pineal peptides on neuroendocrine system after pinealectomy].

Arkhiv patologii2001PMID: 11452647

Animal StudyEpitalon

Plain Language Summary

Pinealectomy caused structural and functional disruption of gastric endocrine cells and thyroid C-cells in rats, and injection of epitalon and epithalamin reversed these changes. Epitalon showed higher biological activity than epithalamin in restoring normal neuroendocrine function.

Abstract

Removal of the pineal gland leads to structural and functional rearrangement of gastric endocrine cells and thyroid C-cells in albino rats, as was shown by immunohistological methods and morphometry. Injection of pineal peptides epithalone and epithalamine eliminated these changes. Biological activity of epithalone is believed to be higher than that of epithalamine.

Authors

Khavinson, V Kh; Kvetnoĭ, I M; Popuchiev, V V; Iuzhakov, V V; Kotlova, L N