Immunohistochemical and morphometric analysis of effects of vilon and epithalon on functional morphology of radiosensitive organs.

Bulletin of experimental biology and medicine2001PMID: 11427924

Animal StudyEpitalon

Plain Language Summary

Epitalon and vilon showed distinct effects on radiosensitive organs in rats exposed to gamma irradiation. While vilon stimulated proliferative activity in the thymus and intestinal stem cells to promote post-radiation recovery, epitalon decelerated metabolic processes in the duodenal mucosa and modulated splenic hemopoiesis and lymphopoiesis.

Abstract

Studies of the effects of vilon and epithalon on functional morphology of the thymus, spleen, and duodenum in intact rats and rats exposed to single whole-body gamma-irradiation in a dose of 6 Gy showed that vilon stimulated proliferative activity of thymocytes and enhanced proliferative potential of stem cells in the intestine, thus stimulating the postradiation recovery of critical organs. Epithalon decelerated metabolic processes in the duodenal mucosa and suppressed hemopoiesis and lymphopoiesis in the spleen.

Authors

Khavinson, V K; Yuzhakov, V V; Kvetnoi, I M; Malinin, V V; Popuchiev, V V; Fomina, N K