Peptidergic correction of the effect of acute hypobaric hypoxia in pregnant rats on progeny.

Bulletin of experimental biology and medicine20011 citationPMID: 11391386

Animal StudySemax

Plain Language Summary

This animal study examined how Semax peptide corrects the effects of acute hypobaric hypoxia during pregnancy on offspring. Peptidergic treatment with Semax during the critical period attenuated developmental disturbances in rat pups caused by maternal hypoxia exposure.

Abstract

Acute hypobaric hypoxia of pregnant rats led to a significant delay in body weight gain, growth and time of eye opening in newborn rat pups which was paralleled by behavioral changes. Preventive intranasal instillations of peptide mixture (semax and beta-casomorphine-7) to pregnant females prevented the effect of hypoxia on the progeny.

Authors

Maslova, M V; Zemlyanskii, K S; Shkol'nikova, M V; Maklakova, A S; Krushinskaya, Y V; Sokolova, N A; Ashmarin, I P