Peptide bioregulators inhibit apoptosis.

Bulletin of experimental biology and medicine2000PMID: 11276315

Animal StudyEpitalon

Plain Language Summary

Epitalon and vilon both inhibited radiation-induced apoptosis in rat spleen lymphocytes, demonstrating that these peptide bioregulators can suppress programmed cell death. The anti-apoptotic effects support the concept that peptide bioregulators have tissue-specific protective actions.

Abstract

The effects of peptide bioregulators epithalon and vilon on the dynamics of irradiation-induced apoptotic death of spleen lymphocytes in rats indicate that these agents inhibit physiologically programmed cell death. The antiapoptotic effect of vilon was more pronounced, which corroborates the concept on tissue-specific effect of peptide bioregulators.

Authors

Khavinson, V K; Kvetnoii, I M